This lecture was partially supported by the National Priority Areas Initiative (Asthma), Department of Health and Ageing, Australia

¹National Centre for Epidemiology and Population Health Australian National University, Canberra^{2Menzies Centre for Population Health Research University of
Tasmania, Hobart, Australia
^{3Department of Immunology, Royal Children�s
Hospital, University of Melbourne, Melbourne
^{4Department of Biostatistics, University of North
Carolina at Chapel Hill, Chapel Hill, NC
^{5Department of Paediatrics and Child Health,
University of Tasmania, Hobart, Australia}}}}