Jeffrey Fine MD

About me

I am a breast and gynecologic pathologist with research interests in Computational Pathology, in vivo microscopy (IVM), multiplexed image analysis, whole slide images (WSIs), telepathology, and other digital pathology topics. One application of computational pathology is Computer Assisted Diagnosis for Pathologists (pCAD), which is a novel paradigm for 21st century workflow. I will construct a link to a pCAD page in a bit (I am overhauling the webpage).

On a side note, I have been creating web sites for myself ever since 1994, which is an eternity on the WWW. The current site ties into my Pathology Informatics interests because it uses a combination of HTML and CSS (cascading style sheets). One key component of my pCAD construct is that laboratory information system (LIS) data would be more machine readable than it is now. A combination of structured data and WWW-type display technology could be a very powerful new way for pathologists to create and communicate their diagnoses. This is an ongiong project and as it gets written up I'll include a page on this site. In the meantime, another website called "CSS Zen Garden" demonstrates the power of such a system using CSS (link opens in new window).

Education and Training

  • Pathology Informatics Fellowship - UPMC, 2006
  • Certificate, Biomedical Informatics - U. Pittsburgh, 2006
  • Pathology Residency - Cleveland Clinic, 2005
  • MD - Ohio State University, 2000
  • BS - Cellular & Molecular Biology, U. Michigan, 1995 (with Honors)

Clinical Expertise

  • Breast and Gynecologic Pathology
  • Image Analysis
  • Telepathology
  • Whole Slide Imaging (WSI)

Research Interests

  • Computational Pathology, including computer assisted diagnosis for pathologists (pCAD)
  • In vivo / ex vivo microscopy (IVM and EVM)--I currently use Optical Coherence Tomography (OCT)
  • Whole Slide Imaging (WSI) - clinical applications, R&D, telepathology
  • MultiSpectral Imaging (MSI)

Collaborators

Students and Trainees

  • Luong Nguyen - PhD student in Computational & Systems Biology
  • Dan Spagnolo - PhD student in Computational & Systems Biology
  • Matthew Hanna, M.D. - Pathology Informatics Fellow 2016-2017
  • Michelle Heayn, M.D., Ph.D. - Pathology Resident
  • Terri Jones - Senior Medical Student
  • Daniel Gonzalez - Senior Medical Student
  • Dinesh Pradhan, M.D., M.B.B.S. - Pathology Resident

Former Students and Trainees

  • Navid Farahani, M.D. - Pathology Informatics Fellow 2015-2016, now VP of Computational Pathology at 3Scan
  • Greg Gurda, M.D. - Breast / Gynecologic Pathology Fellow (2014-2015), now at Gundersen Health System
  • H. Marais Combrinck, FRCPA, MBChB - 4-month mini fellowship in Pathology Informatics 2014; Pathologist at PathWest in Perth, Australia
  • Alexis Bruhat - 4-month biomedical engineering internship 2014 (from Paris Descartes University in France); now a graduate student in biomedical engineering at Columbia University (New York)
  • M. Asim Syed, M.D. - Pathology Informatics Fellow
  • Daman Samrao, M.D. - Breast / Gynecologic Pathology Fellow (2013-2014), now in private practice in Las Vegas
  • Ioan Cucoranu, M.D. - Pathology Informatics Fellow 2012-2013, now in Industry and consulting (Florida)
  • Seung Park, M.D. - Pathology Informatics Fellow 2011-2013, Associate Chief CMIO at Community Health Systems in Tennessee
  • Gaurav Sharma, M.D. - Pathology Informatics Fellow, now faculty at Henry Ford Health System (Detroit)
  • Joe Sirintrapun M.D. - Pathology Informatics Fellow, now director of pathology informatics at Memorial Sloan Kettering Cancer Center in New York

Other

  • Japan Exchange and Teaching Program Alumnus (Ibaraki-ken, Japan) (茨城県下妻市の教育委員会でした。)

Work Links

Selected Publications

  • Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC. Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers. J Pathol Inform. 2016;7:47. PMID:27994939
  • Cao C, Vasilatos SN, Bhargava R, Fine JL, Oesterreich S, Davidson NE, Huang Y. Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression. Oncogene. 2016 May 23; Advance online publication (PMID: 27212032).
  • Farahani N, Post R, Duboy J, Ahmed I, Kolowitz BJ, Krinchai T, Monaco SE, Fine JL, Hartman DJ, Pantanowitz L. Exploring virtual reality technology and the Oculus Rift for the examination of digital pathology slides. J Pathol Inform. 2016;7:22. PMID: 27217972
  • Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Dec;6(5-6):214-24. PMID: 26113056
  • Fine JL. 21st Century Workflow: A Proposal. J Pathol Inform 2014, 5:44 (PMID: 25535592).
  • Durkin JR, Fine JL, Sam H, Pugliano-Mauro M, Ho J. Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study. Dermatol Surg, 2014 Mar;40(3):266-74 (doi: 10.1111/dsu.12419).
  • Sellaro TL, Filkins R, Hoffman C, Fine JL, Ho J, Parwani AV, Pantanowitz L, Montalto M. Relationship between magnification and resolution in digital pathology systems. J Pathol Inform 2013 Aug 22;4:21 (DOI: 10.4103/2153-3539.116866).
  • Yu J, Monaco SE, Onisko A, Bhargava R, Dabbs DJ, Cieply KM, Fine JL.  A validation study of quantum dot multispectral imaging to evaluate hormone receptor status in ductal carcinoma in situ (DCIS) of the breast. Hum Pathol. 2013 Mar;44(3):394-401 (doi:10.1016/j.humpath.2012.06.002).
  • Fine JL. Comment on "Modified full-field optical coherence tomography: A novel tool for rapid histology of fresh tissues". J Pathol Inform. 2011;2:28 (DOI: 10.4103/2153-3539.82054).
  • Fine JL, Kagemann L, Wollstein G, Ishikawa H, Schuman JS. Direct scanning of pathology specimens using spectral domain optical coherence tomography: a pilot study. Ophthalmic Surg Lasers Imaging. 2010; 41:S58-S64 (doi: 10.3928/15428877-20101031-05).
  • Fine JL, Grzybicki DM, Silowash R, Ho J, Gilbertson JR, Anthony L, Wilson R, Parwani AV, Bastacky SI, Epstein JI, Jukic DM. Evaluation of Whole Slide Image Immunohistochemistry Interpretation in Challenging Prostate Needle Biopsies. Hum Pathol. 39(4):564-72. 2008 (doi: 10.1016/j.humpath.2007.08.007).
  • Horbinski C, Fine JL, Medina-Flores R, Yagi Y, Wiley CA. Telepathology for Intraoperative Neuropathologic Consultations at an Academic Medical Center: A 5-Year Report. J Neuropathol Exp Neurol, 66(8):750-9. 2007 (PMID: 17882019).