Alexandre Dombrovski, MD
Assistant Professor of Psychiatry at the University of Pittsburgh
dombrovskia at upmc.edu
Work on late-life suicide
Our lab uses behavioral experiments and neuroimaging to understand decision processes leading to suicidal behavior. We work with older adults who have attempted suicide. Suicide, especially in old age, is often viewed as a strategic, rational decision. In contrast, we argue that the suicidal crisis often escalates unexpectedly. Catastrophic choices follow a failure to consider present experiences in the context of prior knowledge and values.
Luke Clark (Univ. of Cambridge)
Suicide decision lab staff
Natalie Truty, Jan Kalkus, Modhurima Moitra, Mandy Collier
Learning: finding the best choices by trial and error
Dombrovski, A.Y., Clark, L., Siegle, G.J., Butters, M., Ichikawa, N., Sahakian, B., Szanto, K., Reward/Punishment Reversal Learning in Older Suicide Attempters. Am J Psychiatry. 2010: appi.ajp.2009.09030407. Free full text
Dombrovski AY*, Szanto K., Clark L, Reynolds 3rd CF, Siegle, GJ. Reward signals, impulsivity, and attempted suicide in late-life depression. JAMA Psychiatry, 2013; 70(10):1020-103. Free full text Author material
Value-based decisions: one-shot choices
Clark L, Dombrovski AY, Siegle GJ, Butters MA, Shollenberger C, Sahakian BJ, Szanto K. in press. Impairment in risk-sensitive decision-making in older suicide attempters. Psychology and Aging. Free full text
Dombrovski AY, Szanto K, Siegle GJ, Wallace ML, Forman SD, Sahakian B, Reynolds CF, Clark L. (2011) Lethal Forethought: Delayed Reward Discounting Differentiates High- and Low-Lethality Suicide Attempts in Old Age. Biological Psychiatry. Free full text
Dombrovski AY, Siegle GJ, Szanto K, Clark L, Reynolds CF, Aizenstein H. The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychol Med. 2011 Oct 17:1-13. PubMed Free full text Full Text
Cognitive control: representing the goals and structure of the task
Dombrovski AY, Butters MA, Reynolds CF, Houck PR, Clark L, Mazumdar S, Szanto K. Cognitive performance in suicidal depressed elderly: preliminary report. American Journal of Geriatric Psychiatry, 16(2): 109-115.
Gujral S, Dombrovski AY*, Butters M, Clark L, Reynolds 3rd CF, Szanto K. Impaired Executive Function in Contemplated and Attempted Suicide in Late Life. American Journal of Geriatric Psych, in press. PubMed
Szanto K, Clark L, Hallquist M, Vanyukov P, Crockett M, Dombrovski AY. The cost of social punishment and high-lethality suicide attempts in the second half of life. Psychology and Aging, in press
Late-life suicide, pharmacotherapy of late-life depression, and psychiatric phenomenology.