Alexandre Dombrovski, MD
Assistant Professor of Psychiatry at the University of Pittsburgh
dombrovskia at upmc.edu
I study decision processes involved in suicidal behavior, using behavioral experiments and brain imaging. People prone to suicide have difficulty making decisions in general. This can be seen, for example, from the overlap between suicide, addiction and gambling. I try to understand the nature of this difficulty and the brain features that may underlie it.
Luke Clark (Univ. of Cambridge)
Suicide lab staff
Natalie Truty, Jan Kalkus, Rima Moitra, Mandy Collier
Learning: finding the best choices by trial and error
Dombrovski, A.Y., Clark, L., Siegle, G.J., Butters, M., Ichikawa, N., Sahakian, B., Szanto, K., Reward/Punishment Reversal Learning in Older Suicide Attempters. Am J Psychiatry. 2010: appi.ajp.2009.09030407. Free full text
Dombrovski AY*, Szanto K., Clark L, Reynolds 3rd CF, Siegle, GJ. Reward signals, impulsivity, and attempted suicide in late-life depression. JAMA Psychiatry, in press. Author material
Value-based decisions: one-shot choices
Clark L, Dombrovski AY, Siegle GJ, Butters MA, Shollenberger C, Sahakian BJ, Szanto K. in press. Impairment in risk-sensitive decision-making in older suicide attempters. Psychology and Aging. Free full text
Dombrovski AY, Szanto K, Siegle GJ, Wallace ML, Forman SD, Sahakian B, Reynolds CF, Clark L. (2011) Lethal Forethought: Delayed Reward Discounting Differentiates High- and Low-Lethality Suicide Attempts in Old Age. Biological Psychiatry. Free full text
Dombrovski AY, Siegle GJ, Szanto K, Clark L, Reynolds CF, Aizenstein H. The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychol Med. 2011 Oct 17:1-13. PubMed Full Text
Cognitive control: representing the goals and structure of the task
Dombrovski AY, Butters MA, Reynolds CF, Houck PR, Clark L, Mazumdar S, Szanto K. Cognitive performance in suicidal depressed elderly: preliminary report. American Journal of Geriatric Psychiatry, 16(2): 109-115.
Gujral S, Dombrovski AY*, Butters M, Clark L, Reynolds 3rd CF, Szanto K. Impaired Executive Function in Contemplated and Attempted Suicide in Late Life. American Journal of Geriatric Psych, in press. PubMed
Late-life suicide, pharmacotherapy of late-life depression, and psychiatric phenomenology.